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New Study Evaluates the Feasibility of Using Masimo EMMA® Capnography on Mechanically Ventilated Neonates

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New Study Evaluates the Feasibility of Using Masimo EMMA® Capnography on Mechanically Ventilated Neonates

Business Wire India

Masimo (NASDAQ: MASI) today announced the findings of a study published in the European Journal of Pediatrics in which Dr. Masashi Hotta and colleagues at the Osaka Women’s and Children’s Hospital in Japan found that the Masimo EMMA® Portable Capnograph “may be considered an effective monitoring device” for mechanically ventilated preterm infants (neonates).1

 

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20210926005040/en/

 

Masimo EMMA® (Photo: Business Wire)

Noting the importance of maintaining an appropriate range of partial pressure of arterial carbon dioxide (PaCO2) in preterm infants, especially while undergoing mechanical ventilation in the neonatal intensive care unit (NICU), the researchers sought to evaluate whether noninvasively monitoring end-tidal carbon dioxide (EtCO2) with EMMA could help clinicians maintain neonatal PaCO2 in the delivery room. They chose EMMA not only because of its portability but because it offers a solution with a small dead space (1 mL). The researchers enrolled 40 neonates (gestational age of 26+0 to 31+6 weeks) who required intubation in the delivery room (the EMMA monitoring group) and compared their PaCO2 value, either at admission to the NICU or 2 hours after birth, with that of 43 infants who did not undergo EMMA monitoring (the historical control group). They defined “appropriate” PaCO2 as 35 – 60 mmHg, as measured using a blood gas analyzer.

 

The researchers found that the proportion of infants with appropriate PaCO2 was greater in the EMMA group than in the control group (80% vs. 42%, p = 0.001). Stratified according to birth weight (< 1000 g vs. > 1000 g), they found that in smaller neonates, there was no significant difference in the proportion of infants with appropriate PaCO2 between groups, but in the larger cohort, the rate of appropriate PaCO2 was significantly higher in the EMMA group: 93% vs. 44%, p < 0.001.

 

The study authors concluded that EMMA “facilitated the maintenance of an appropriate PaCO2 for mechanically ventilated pre-term infants, especially infants with birth weight ≥ 1000 g, in the delivery room.” They noted that the main strength of their study was that they “collected intervention data prospectively and showed the feasibility of using a portable capnometer during resuscitation of intubated preterm infants” – the first study of its kind.

 

EMMA provides seamless mainstream capnography for patients of all ages in a compact, easily portable device. The instrument requires no routine calibration and minimal warm-up time, with accurate EtCO2 and respiration rate measurements and continuous EtCO2 waveforms displayed within 15 seconds.

 

EMMA does not have FDA clearance for neonates.

 

@Masimo | #Masimo

 

About Masimo

 

Masimo (NASDAQ: MASI) is a global medical technology company that develops and produces a wide array of industry-leading monitoring technologies, including innovative measurements, sensors, patient monitors, and automation and connectivity solutions. Our mission is to improve patient outcomes and reduce the cost of care. Masimo SET® Measure-through Motion and Low Perfusion™ pulse oximetry, introduced in 1995, has been shown in over 100 independent and objective studies to outperform other pulse oximetry technologies.2 Masimo SET® has also been shown to help clinicians reduce severe retinopathy of prematurity in neonates,3 improve CCHD screening in newborns,4 and, when used for continuous monitoring with Masimo Patient SafetyNet™ in post-surgical wards, reduce rapid response team activations, ICU transfers, and costs.5-8 Masimo SET® is estimated to be used on more than 200 million patients in leading hospitals and other healthcare settings around the world,9 and is the primary pulse oximetry at 9 of the top 10 hospitals as ranked in the 2021-22 U.S. News and World Report Best Hospitals Honor Roll.10 Masimo continues to refine SET® and in 2018, announced that SpO2 accuracy on RD SET® sensors during conditions of motion has been significantly improved, providing clinicians with even greater confidence that the SpO2 values they rely on accurately reflect a patient’s physiological status. In 2005, Masimo introduced rainbow® Pulse CO-Oximetry technology, allowing noninvasive and continuous monitoring of blood constituents that previously could only be measured invasively, including total hemoglobin (SpHb®), oxygen content (SpOC™), carboxyhemoglobin (SpCO®), methemoglobin (SpMet®), Pleth Variability Index (PVi®), RPVi™ (rainbow® PVi), and Oxygen Reserve Index (ORi™). In 2013, Masimo introduced the Root® Patient Monitoring and Connectivity Platform, built from the ground up to be as flexible and expandable as possible to facilitate the addition of other Masimo and third-party monitoring technologies; key Masimo additions include Next Generation SedLine® Brain Function Monitoring, O3® Regional Oximetry, and ISA™ Capnography with NomoLine® sampling lines. Masimo’s family of continuous and spot-check monitoring Pulse CO-Oximeters® includes devices designed for use in a variety of clinical and non-clinical scenarios, including tetherless, wearable technology, such as Radius-7® and Radius PPG™, portable devices like Rad-67®, fingertip pulse oximeters like MightySat® Rx, and devices available for use both in the hospital and at home, such as Rad-97®. Masimo hospital automation and connectivity solutions are centered around the Masimo Hospital Automation™ platform, and include Iris® Gateway, iSirona™, Patient SafetyNet, Replica™, Halo ION™, UniView®, UniView :60™, and Masimo SafetyNet™. Additional information about Masimo and its products may be found at www.masimo.com. Published clinical studies on Masimo products can be found at www.masimo.com/evidence/featured-studies/feature/.

 

ORi and RPVi have not received FDA 510(k) clearance and are not available for sale in the United States. The use of the trademark Patient SafetyNet is under license from University HealthSystem Consortium.

 

References

 

Hotta M, Hirata K, Nozaki M, Mochizuki N, Hirano S, and Wada K. Feasibility of portable capnometer for mechanically ventilated preterm infants in the delivery room. Eur J Ped. 2021. DOI:10.1007/s00431-021-04246-1.
Published clinical studies on pulse oximetry and the benefits of Masimo SET® can be found on our website at http://www.masimo.com. Comparative studies include independent and objective studies which are comprised of abstracts presented at scientific meetings and peer-reviewed journal articles.
Castillo A et al. Prevention of Retinopathy of Prematurity in Preterm Infants through Changes in Clinical Practice and SpO2 Technology. Acta Paediatr. 2011 Feb;100(2):188-92.
de-Wahl Granelli A et al. Impact of pulse oximetry screening on the detection of duct dependent congenital heart disease: a Swedish prospective screening study in 39,821 newborns. BMJ. 2009;Jan 8;338.
Taenzer A et al. Impact of pulse oximetry surveillance on rescue events and intensive care unit transfers: a before-and-after concurrence study. Anesthesiology. 2010:112(2):282-287.
Taenzer A et al. Postoperative Monitoring – The Dartmouth Experience. Anesthesia Patient Safety Foundation Newsletter. Spring-Summer 2012.
McGrath S et al. Surveillance Monitoring Management for General Care Units: Strategy, Design, and Implementation. The Joint Commission Journal on Quality and Patient Safety. 2016 Jul;42(7):293-302.
McGrath S et al. Inpatient Respiratory Arrest Associated With Sedative and Analgesic Medications: Impact of Continuous Monitoring on Patient Mortality and Severe Morbidity. J Patient Saf. 2020 14 Mar. DOI: 10.1097/PTS.0000000000000696.
Estimate: Masimo data on file.
http://health.usnews.com/health-care/best-hospitals/articles/best-hospitals-honor-roll-and-overview.

Forward-Looking Statements

 

This press release includes forward-looking statements as defined in Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, in connection with the Private Securities Litigation Reform Act of 1995. These forward-looking statements include, among others, statements regarding the potential effectiveness of EMMA®. These forward-looking statements are based on current expectations about future events affecting us and are subject to risks and uncertainties, all of which are difficult to predict and many of which are beyond our control and could cause our actual results to differ materially and adversely from those expressed in our forward-looking statements as a result of various risk factors, including, but not limited to: risks related to our assumptions regarding the repeatability of clinical results; risks related to our belief that Masimo’s unique noninvasive measurement technologies, including EMMA, contribute to positive clinical outcomes and patient safety; risks related to our belief that Masimo noninvasive medical breakthroughs provide cost-effective solutions and unique advantages; risks related to COVID-19; as well as other factors discussed in the “Risk Factors” section of our most recent reports filed with the Securities and Exchange Commission (“SEC”), which may be obtained for free at the SEC’s website at www.sec.gov. Although we believe that the expectations reflected in our forward-looking statements are reasonable, we do not know whether our expectations will prove correct. All forward-looking statements included in this press release are expressly qualified in their entirety by the foregoing cautionary statements. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of today’s date. We do not undertake any obligation to update, amend or clarify these statements or the “Risk Factors” contained in our most recent reports filed with the SEC, whether as a result of new information, future events or otherwise, except as may be required under the applicable securities laws.

 

 

View source version on businesswire.com: https://www.businesswire.com/news/home/20210926005040/en/

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Press Release

The Open Group Organizes Sensitization Session on ISO/IEC 20243-2018 (O-TTPS) for Government Organizations in India

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The Open Group Organizes Sensitization Session on ISO/IEC 20243-2018 (O-TTPS) for Government Organizations in India

Business Wire India

The Open Group, a vendor-neutral technology standards consortium, hosted a virtual sensitization session on ISO/IEC 20243-2018 [Open Trusted Technology Provider™ Standard (O-TTPS)] for Senior Indian Government Officials and Regulators on Thursday, 2nd December 2021.

In continuation to The Open Group ongoing endeavor in building awareness and adoption of this standard in India, it organized a virtual session which was the first of its kind sensitization session. The session shared information about the standard, its usage in different industries and departments, and use cases from government-wide procurement process in the US Government. It was attended by seventy officers from the Ministry of Electronics and Information Technology, Ministry of Power, Standardisation Testing and Quality Certification, Centre for Development of Advanced Computing, National Informatics Centre, Central Power Research Institute, Indian Railways, and Indian Institute of Science.

The Open Group provided an overview of the standard and industries where it is being adopted. The O-TTPS is a set of guidelines, recommendations, and requirements that help address the issue of maliciously tainted and counterfeit hardware and software products throughout the commercial off-the-shelf (COTS) information and communication technology product lifecycles. The standard includes best practices throughout all phases of the product life cycle spanning design, sourcing, development, fulfillment, distribution, sustenance, and disposal, thus enhancing the integrity of technology products and the security of their global supply chains. More information about the standard is available at:
 

https://www.iso.org/standard/74399.html
https://www.iso.org/standard/74400.html

Joanne Woytek, Program Manager from NASA‘s Solution for Enterprise-Wide Procurement (SEWP) provided insights into the use of the standard by their supplier group and its valuable contribution in enhancing the procurement process. The SEWP is a premier Government-Wide Acquisition Contract (GWAC) providing federal agencies access to the latest in Information and Communication Technology product solutions, managed by NASA.

The main points and the key takeaways from the session were:

The significance of the standard against maliciously tainted and counterfeit hardware and software products throughout commercial off-the-shelf information and communication technology product lifecycles.

NASA’s use of the standard while being aware that there is some risk and uncertainly involved in the supply chain and being vigilant about it as an imperative. Additionally, ensuring that the process of education and keeping their customer/suppliers updated and aware about their policies and standard usage.

The role of the standard for India in securing India’s critical infrastructures like Power, Telecom, Railways, and Banking. The need for wider awareness among various stakeholders covering consumers, integrators, component suppliers, certification authority, and standards bodies was accentuated during the interactions.

The necessity to create an implementation guide suited to the Indian context and its industries. This will help in a better understanding of the standard and its adoption process for various industries that use information and communication technology products.

In his keynote address at the Sydney Dialogue on 18th November 2021, Prime Minister Modi spoke about India’s efforts towards creating and operating with trusted supply chains. In this regard, the Department of Telecom launched the Trusted Telecom Portal effective from June 15th, 2021. Taking the same thread forward with concrete action, the Standardisation Testing and Quality Certification (STQC) Directorate of the MeitY has recently launched the Trusted Electronics Value Chain Certification Scheme (TEVCCS). This scheme is derived from and aligned with the ISO 20243:2018. This impacts design, development, manufacturing, procurement, and deployment activities in the entire telecom sector. After the Telecom Sector, India released the cybersecurity guidelines for the power sector. There is a heavy emphasis on trusted providers in the Power Sector’s Cybersecurity Guidelines with two of its main objectives being the reduction of cyber supply chain risks and use of open standards and in that context the O-TTPS being mentioned as one of the standards for compliance signaling the relevance and timeliness of the session.

The Open Group has constantly strived to lead the field in technology standards services, certifications, research, and training worldwide. “With supply chain cybersecurity emerging as one of the most important priorities in protecting our critical infrastructures, this sensitization session demonstrates our vision and commitment to open standards and accentuating its adoption as a public good. We aim to continue more such sessions to cover other stakeholders in India,” states Dr. Pallab Saha, General Manager, The Open Group (India).

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Press Release

CertiK Closes Largest Investment Round in Blockchain Security from Sequoia, Bringing its Valuation to Nearly $1 Billion

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CertiK Closes Largest Investment Round in Blockchain Security from Sequoia, Bringing its Valuation to Nearly $1 Billion

Business Wire India

CertiK, the leading global blockchain security firm headquartered in New York, today announced the completion of an $80 million Series B2 financing round. This investment is led by Sequoia, with participation from existing investors including Tiger Global, Coatue Management, and GL Ventures (Hillhouse Capital’s VC arm). This not only sets the bar for the largest single round of fundraising in the blockchain security space but now brings CertiK’s valuation to nearly $1 Billion. This is the third round of capital raised by CertiK within four months, altogether totaling just over $140M.

 

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20211201005593/en/

 

CertiK cofounders Ronghui Gu (left) and Zhong Shao (right) (Photo: Business Wire)

There has been a substantial increase in demand for blockchain security in the past few years – mostly driven by recent blockchain hacks, and stolen cryptocurrency. In 2021, $1.3 billion in cryptocurrency was lost to hacks, exploits, and scams – a large increase from the over $500 million dollars lost in 2020.

 

CertiK has experienced incredible growth over the past year, increasing revenues by 20x and its headcount by 4x. To date, CertiK has provided security products and services to over 1,800 clients, detected over 31,000 vulnerabilities in blockchain code, and protected over $310 billion worth of digital assets.

 

“Blockchain security is an indispensable link in the commercial value chain overall,” said a Sequoia spokesperson. “We are very proud to invest in CertiK, which is deeply involved in this field. This is an important addition to our global blockchain investment landscape. We believe that CertiK can create synergies with other companies we have invested in. Our goal is that Sequoia can provide CertiK with resources to jointly develop the blockchain security market.”

 

In addition to blockchain and smart contract auditing and formal verification through its Security Leaderboard platform, CertiK launched Skynet, the first 24/7, active-monitoring platform. Skynet monitors and protects smart contracts as well as blockchains against sophisticated security threats. As the security threat landscape continues to evolve, Skynet’s strategy is to utilize large amounts of on-chain and off-chain machine learning data. With this data Skynet can adapt and evolve, to protect smart contracts and blockchains against new threats. Both Security Leaderboard and Skynet are seeing incredible growth. Since the end of 2020, Skynet’s booked revenue has grown 2,300%, and the total number of users on the Security Leaderboard has grown 2,000%.

 

The newly raised capital coupled with revenue generated from both Skynet and Security Leaderboard, will be used for the development and operation of more innovative products. “Smart contract auditing and formal verification are the first steps in a blockchain security service,” CertiK Co-founder, Professor Ronghui Gu pointed out. “CertiK’s goal will be to develop more SaaS products to provide additional security benefits for clients. This includes security auditing, formal verification, monitoring, detection, as well as protection of client blockchain and smart contracts.”

 

CertiK strives to create a leadership team composed of the best talent. Dr. David Tarditi, who recently joined CertiK as Vice President of Engineering, has over 16 years of experience growing and leading engineering and research teams at Microsoft. He is also the inventor and co-inventor of 22 patents and has carried out research on typed intermediate languages, which gives compiler developers proof of compiler phases maintaining key correctness properties of input source code. In addition, Monier Jalal, who has over 20 years of leadership in the cybersecurity space, has also joined CertiK as Vice President of Marketing. Mr. Jalal has helped companies successfully market and launch products and has been part of the founder and executive leadership team driving the growth, acquisition, and IPO for several cybersecurity startups.

 

About CertiK

 

CertiK’s mission is to secure the cyber world. Starting with blockchain, CertiK applies cutting-edge innovations from academia into enterprise, enabling mission-critical applications to be built with security and correctness. Headquartered in New York City, CertiK was founded by computer science professors at Yale University and Columbia University. CertiK is backed by industry leaders, including Sequoia, Coatue Management, Tiger Global, GL Ventures (Hillhouse Capital’s venture arm), Binance, Coinbase Ventures, Lightspeed, and more

 

 

View source version on businesswire.com: https://www.businesswire.com/news/home/20211201005593/en/

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Press Release

EasyCollect by Easebuzz – A Complete API Integration Toolkit for Growing Businesses in India

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EasyCollect by Easebuzz – A Complete API Integration Toolkit for Growing Businesses in India

Business Wire India
Easebuzz has set its foot in the digital world in 2016 and launched its operations with a gamut of digital payment solutions to help SMEs with digital payment issues and offer them scalable and reliable solutions that allow them to grow seamlessly in the competitive market.

Early-stage growing businesses in India encounter dire problems as they grow and end up with a high-cost center for solving such issues with banks or other financial institutions. Easebuzz comes with a motive to help businesses with smart APIs and cost-effective solutions all in one single place. It’s a well-established software platform, embedded with payment infrastructure aiding businesses to accept, process, and disburse payments with its API-based product suite.

Amit Kumar, CTO and Director of Easebuzz stated, – “At Easebuzz we are recognized as a “Collection Gateway” and act as a “Technology Partner” for growing businesses and enterprises in India. Our core focus is towards resolving problems related to collection mechanisms at the least cost with help of unique product offerings.

In today’s world, online payment transactions are setting standards whereas cash is becoming an impediment. Moreover, irrespective of their retail foothold, there is a dire atmosphere created for businesses to have online payment options that can further ensure their indispensable digital presence. Technology, on the other hand, is a double-edged sword. In spite of the multitude of advantages offered by technology, there still are problems faced by emerging businesses in India.
 
Easebuzz has identified and solved these primary problems by establishing a software platform that is integrated with payment infrastructure. EasyCollect is one of Easebuzz’s innovative SME offerings which is a complete API integrated toolkit for developing enterprises. This product accepts a variety of payment methods and speeds, including real-time transactions. Customers can quickly and easily make a payment that suits their needs and communicate further via SMS, Email, or WhatsApp.
 
The automated payment reminders help in reducing manual follow-ups, reconciliation and allow to customize e-mail and SMS content for follow-ups at the click of a button. It helps in managing all the payment-related activities from a single dashboard. Automated payment reminders make digital payment simple, and the seven-step procedure is reduced to just three steps i.e.,

Login
Set payment automation
Receive payment.

 
EasyCollect is a value-added API-driven software that is favored over any traditional payment link solution in the industry due to its unique features that contribute to a hassle-free payment.  Following are the key characteristics of EasyCollect:

Auto-Generated Invoice – Send auto-generated invoice detail to customers
Voice-Enabled Bot – For Payment reminders & marketing activities
Real – Time Updates – Real-Time payment updates are available 24×7, 365 days
Automation – Reduction of manual follow ups and reconciliation
Customize Email & SMS – Follow up with the click of a button
Single Dashboard – Multiple adaptations in one place for a quick overview

  
Reconciliation, Split Payment, Auto Payment, and Bulk Payment made easier with EasyCollect:
 
Real-time reconciliation of transactions into ERP systems can be easily done with the help of EasyCollect. This comprises transaction ID and transaction details which are gathered on the gateway by selecting the required data and format to properly integrate with the accounting system of choice. 
 
Speaking of bulk payment, with EasyCollect you can send payment links in bulk by uploading a batch file on the EasyCollect Dashboard. Additionally, Wire- a flagship product of Easebuzz facilitates split payment that can be integrated, with EasyCollect for merchants who require their payments to be split between different vendors.
 
EasyCollect by Easebuzz automates recurring bill payments, manages advance payment collection and subscriptions with great ease using APIs. It automates the reminder overpayment collections for any merchant that has a due date-based collection mechanism. Easebuzz has partnered with over 100 merchants on a monthly basis, resulting in over 219 lifetime EasyCollect merchants.

The customer can operate EasyCollect with ease as per the following step:

Create a simple payment link via Easebuzz Dashboard and customize it.
Share Payment links via SMS, Email, or Whatsapp and get paid instantly.
Automate your payment collection with invoice payment reminders before the Due Date of an Invoice.
Create and share payment links for multiple customers in one go by uploading a bulk file.
Manage your transactions, refunds, and settlements from one single dashboard.
Quickly remind customers about due bill dates with our Outbound IVR Service feature.
Get notified when there is a change in the status of the transaction.

 
These features allow EasyCollect customers to pay during any point of time and can easily fulfill their bills or invoice related to pending payments such as maintenance bills, school fees, insurance, and other obligation manual reminders. This saves time and cost both for the merchants as well as for the customers.
 
Mr. Rohit Prasad, CEO and MD of Easebuzz stated – “Easycollect is a cutting-edge API-based solution to enable diverse small and medium-sized enterprises to process digital payments and collections.”
 
Easebuzz, a preferred partner for SMEs across India, is working towards its long term aim of establishing itself as a payment collection/SaaS software solutions company with an API module tailored for Indian startups and SMEs.

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